musings on music and life

January 1, 2016

Latest paper

Filed under: Chemistry — Tags: — sankirnam @ 7:31 pm

So this actually came out over a month ago, but I couldn’t get around to posting about it until now. Link for those interested. The sad part is that I currently cannot access this, even though it is my own work!

The research in this paper was developed as part of my thesis work on superelectrophilic activation, in order to develop new electrophiles for Friedel-Crafts reactions.

This is the only place where I can mention the contributions of an undergraduate student who worked with me on this project – Mr. Billy Stevens. I don’t know why his name was omitted from the list of authors on this paper, even though I had reminded my advisor to include his name multiple times.

This paper originated from work we had previously carried out on the superelectrophilic activation of acrylic acids; we found that they could undergo one-pot alkylation and cyclic acylation with arenes. Thus, we extended this work to include thiophenols, as sulfur can serve as an interesting nucleophile under these conditions. I optimized the conditions and prepared a variety of thiochroman-4-ones using crotonic acid; I was also able to extend this to the use of 4,4,4,-trifluorocrotonic acid for the synthesis of trifluoromethylated thiochroman-4-ones, which unfortunately is not included in the Org. Lett. paper.

I’m rather pleased to have a publication in Organic Letters. This is one of the premier journals in the field of organic chemistry, specializing in short communication-style reports, rather than full-length articles or reviews. Even though the journal started very recently (1999), it is very successful, has a high impact factor, and routinely publishes very interesting, highly-cited papers. At the NOS last year, I got a free Organic Letters shirt, among other things. I suppose wearing this shirt has probably resulted in me getting a paper in this journal, in some karmic fashion.



  1. Congratulations on Organic Letters!

    Comment by Chitti — January 3, 2016 @ 3:27 am

  2. […] for all the compounds I had synthesized. This paper is the continuation of the Organic Letters paper that was published several months ago, and I’m relieved that I finally have a first-author […]

    Pingback by Latest publication | musings on music and life — September 8, 2016 @ 11:06 am

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